Searchable abstracts of presentations at key conferences in endocrinology

ea0029p706 | Diabetes | ICEECE2012

Bile acid binding resins affect diverse molecules to improve metabolic control.

Morimoto K. , Watanabe M. , Houten S. , Kaneko-Iwasaki N. , Sugizaki T. , Horai Y. , Mataki C. , Arita E. , Schoonjans K. , Auwerx J. , Itoh H.

Introduction: Bile acid binding resins (BABRs), anion exchange resins developed as medication for hypercholesterolemia, have been reported to improve glycemic control in patients and animal models with type 2 diabetes mellitus. Although the mechanism has not been clarified yet, we suspect that diverse factors including peripheral bile acid composition and incretins play significant roles in the effect. Besides BABRs, bile acids (BAs) administration has been recently reported t...